Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-Carbomethoxy-4-[(chloroacetyl)amino]thiophene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl 4-aminothiophene-3-carboxylate Hydrochloride | HCID 2777609 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Carbomethoxy-4-[(chloroacetyl)amino]thiophene | HCID 14510003 | — |
반응 단계
A suspension of 12.2 g (0.063 mol) of 3-carbomethoxy-4-aminothiophene hydrochloride in 100 ml of methylene chloride is treated with 10 ml (0.126 mol) of chloroacetyl chloride and subsequently dropwise with 17.6 ml (0.126 mol) of triethylamine, the temperature being held below 25° C. The solution is poured into water and extracted twice with 50 ml of methylene chloride each time. The combined methylene chloride extracts are washed three times with 50 ml of water each time, dried over magnesium sulphate and evaporated. After chromatography on silica gel using methylene chloride for the elution, there is obtained crystalline 3-carbomethoxy-4-[(chloroacetyl)amino]thiophene of melting point 98°-100° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04346032 |
| 출처 데이터셋 | uspto-grants-1982_08 |
| ORD ID | ord-9fc64a80331f4f7b8dc44e2e238bbba8 |
| 출처 메모 | uspto-grants-1982_08 |