Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Benzyloxyindole → 5-benzyloxy-3-(2-nitro-propyl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Benzyloxyindole | HCID 14624 | — |
| 반응물 | 2-Nitro-1-propene | HCID 78486 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 5-benzyloxy-3-(2-nitro-propyl)-1H-indole | HCID 14083171 | — |
반응 단계
To a stirred 0.5 M benzene solution of 5-benzyloxy-1H-indole (6 mL) was added 2-nitro-propene (5.2 mL of the 10% benzene solution). The reaction was heated at reflux under a nitrogen atmosphere overnight. The volatiles were removed and residue was purified by silica gel chromatography (20% EtOAc/hexanes) to afford 5-benzyloxy-3-(2-nitro-propyl)-1H-indole (550 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084154B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-acc4cf61188540a5b8199811016a6ac9 |
| 출처 메모 | uspto-grants-2006_08 |