Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 67591생성일: 2026년 10월 24일
Ethylene Glycol → 2-hydroxyethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
https://huagongshe.com/ko/reaction/67591
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | Flumazenil | HCID 3373 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 생성물 | 2-hydroxyethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate | HCID 20515314 | — |
반응 단계
A mixture of 6.08 g (20 mmol) of ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate, 100 mg of potassium cyanide and 60 ml of ethyleneglycol is stirred at 130° C. for 6 hours and subsequently evaporated. After taking up the residue in chloroform, the solution is washed with water, dried over magnesium sulphate and evaporated. After recrystallisation of the crude product from ethyl acetate, there is obtained 2-hydroxyethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate of melting point 202°-204° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04346036 |
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| 출처 데이터셋 | uspto-grants-1982_08 |
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| ORD ID | ord-e665b9cc8ce2470a89316c8dcc7da5c3 |
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| 출처 메모 | uspto-grants-1982_08 |
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