Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → (6-Aminopyridin-3-yl)(morpholino)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 6-Aminonicotinic acid | HCID 18496 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (6-Aminopyridin-3-yl)(morpholino)methanone | HCID 59259223 | 34.3% |
반응 단계
To a solution of morpholine (9.00 g, 103 mmol) in 400 mL ethanol was added N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (10.0 g, 52.2 mmol), 1-hydroxybenzotriazole (7.00 g, 51.8 mmol), and 6-aminonicotinic acid (6.00 g, 43.4 mmol). After stirring for 18 hours, the resulting solid was filtered. This was triturated with a mixture of 100 mL methanol and 100 mL dichloromethane to yield (6-Amino-pyridin-3-yl)-morpholin-4-yl-methanone (3.08 g, 14.9 mmol). MS (ESI) 208.1 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822457B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-333f6a181a9a4c4b8df2a3415efa8db1 |
| 출처 메모 | uspto-grants-2014_09 |