Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Benzyl-4-(pyridin-3-yl)piperazine → 1-(Pyridin-3-yl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Benzyl-4-(pyridin-3-yl)piperazine | HCID 21815409 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-(Pyridin-3-yl)piperazine | HCID 437234 | 62% |
반응 단계
31.3 g 1-Benzyl-4-pyridin-3-yl-piperazin was hydrogenated at 5 bar on 4 g 10% palladium on charcoal in 300 mL methanol at 50° C. for 25 h. The reaction was filtered. The filtrate was evaporated and purified by chromatography on silica gel (dichlormethane/methanol/ammonia (9/1/0.1)). 12.5 g of the desired compound was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822464B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-fe990aa700d7442d94c6508d1f0b7864 |
| 출처 메모 | uspto-grants-2014_09 |