Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide → 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide | HCID 8469273 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-amino-N-cyclopropyl-4-fluorobenzene-1-sulfonamide | HCID 22019122 | 95.5% |
반응 단계
The mixture of N-cyclopropyl-4-fluoro-3-nitrobenzenesulfonamide (520 mg, 2 mmol) and Pd/C (10%, 100 mg) in EtOH was hydrogenated (1 atm) overnight. The mixture was filtered through a short pad of celite and concentrated in vacuo to afford N-cyclopropyl-4-fluoro-3-aminobenzenesulfonamide (440 mg, 95%) as an ivory solid. LC/MS; (M+H)+=231.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07084160B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-742bd07a01d3417fa9f833046b9b7c41 |
| 출처 메모 | uspto-grants-2006_08 |