Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dichloropyridine → N-(5'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dichloropyridine | HCID 27685 | — |
| 반응물 | N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride | HCID 68289930 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | N-(5'-Chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-N-cyclopropyl-4-oxazol-5-yl-benzamide | HCID 68351885 | — |
반응 단계
The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide hydrochloride and 2,5-dichloro-pyridine following a procedure analogous to that described in Example 19 using N-methylpyrrolidinone as solvent. LC (method 16): tR=0.43 min; Mass spectrum (ESI+): m/z=423 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822471B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-aec1aa3938c14c4d9ff90b04f26816aa |
| 출처 메모 | uspto-grants-2014_09 |