Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → Methyl 5-(bromomethyl)-4-methylthiophene-2-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Methyl 4-methylthiophene-2-carboxylate | HCID 2777593 | — |
| 촉매 | Zinc bromide | HCID 10421208 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Methyl 5-(bromomethyl)-4-methylthiophene-2-carboxylate | HCID 67235212 | — |
반응 단계
To a solution of methyl 4-methylthiophene-2-carboxylate (2.7 g, 6.4 mmol) in dichloromethane (20 mL) is added 48% aq. HBr (12 mL), H2SO4 (6 mL), ZnBr2 (5.4 g), and HCHO (2.2 mL, 37%) at 0-5° C. The mixture is stirred at room temperature for 16 hours. The solution is diluted with water, extracted with dichloromethane, washed with NaHCO3 solution, saturated brine solution, water, dried over sodium sulfate, and concentrated to give the title compound as an off white solid (3.5 g, 81%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822486B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-75a3a1029acb46478cf275d50c0806ed |
| 출처 메모 | uspto-grants-2014_09 |