Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazo[1,2-a]pyridine-6-carbaldehyde → 5-Fluoro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazo[1,2-a]pyridine-6-carbaldehyde | HCID 7164582 | — |
| 반응물 | 5-Fluoroquinoline-6-carbaldehyde | HCID 57917315 | — |
| 반응물 | 3-Bromo-6-(1-methyl-1h-pyrazol-4-yl)-imidazo[1,2-b]pyridazine | HCID 68632486 | — |
| 생성물 | 5-Fluoro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline | HCID 57917488 | — |
반응 단계
(rac)-(5-Fluoro-quinolin-6-yl)-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol was obtained analogously to Stage 9.1 by replacing 3-bromo-6-chloro-imidazo[1,2-b]pyridazine with 3-bromo-6-(1-methyl-1h-pyrazol-4-yl)-imidazo[1,2-b]pyridazine (Stage 8.1) and imidazo[1,2-a]pyridine-6-carbaldehyde with 5-fluoro-quinoline-6-carbaldehyde (Intermediate A) (tR 0.90 min (conditions 1), (MH+=375).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822468B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-439889cdcf884be28c6710a5346c474e |
| 출처 메모 | uspto-grants-2014_09 |