Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester → 6-(1-Ethyl-1H-pyrazol-4-yl)-3-imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Ethyl-1H-pyrazole-4-boronic acid, pinacol ester | HCID 11379045 | — |
| 반응물 | 6-Chloro-3-imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazine | HCID 44208571 | — |
| 생성물 | 6-(1-Ethyl-1H-pyrazol-4-yl)-3-imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazine | HCID 57917389 | — |
반응 단계
The title compound was prepared in analogy to Example 9 using chloro-3-imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazine (Example 74) instead of (rac)-(6-chloro-imidazo[1,2-b]pyridazin-3-yl)-imidazo[1,2-a]pyridin-6-yl-methanol (Stage 9.1) and 1-ethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole instead of 1-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (tR 2.88 min (conditions 3), MH+=344.1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822468B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-01dd41874a2c4ff6a91e542a6b7c7136 |
| 출처 메모 | uspto-grants-2014_09 |