Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(2-Chloroethyl)-4-methoxybenzoyl chloride → 2-[4-(3-Dimethylamino-pyrrolidin-1-yl)-phenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(2-Chloroethyl)-4-methoxybenzoyl chloride | HCID 12401186 | — |
| 반응물 | 1-(4-aminophenyl)-N,N-dimethylpyrrolidin-3-amine | HCID 21916591 | — |
| 생성물 | 2-[4-(3-Dimethylamino-pyrrolidin-1-yl)-phenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one | HCID 68990183 | — |
반응 단계
According to Method A, [1-(4-amino-phenyl)-pyrrolidin-3-yl]-dimethylamine was reacted with 2-(2-chloroethyl)-4-methoxy-benzoyl chloride. The dihydroisoquinolinone thus obtained was treated with hydrogen bromide according to Method L. In this way the product was obtained with molecular weight 351.45 (C21H25N3O2); MS (ESI): 352 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822495B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-bad02b3ce75f4bcaa524b9d91d21c98a |
| 출처 메모 | uspto-grants-2014_09 |