Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → 2-Chloro-5-nitro-4-(piperidin-1-yl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2,4-Dichloro-5-nitropyrimidine | HCID 521266 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Chloro-5-nitro-4-(piperidin-1-yl)pyrimidine | HCID 7147257 | — |
반응 단계
Method 1 was followed using 2,4-dichloro-5-nitropyrimidine (1.0 eq), and piperidine (2.0 eq) in EtOH at 0° C. to rt, yielding after washing with 1M citric acid and 1M HCl (to remove the bis addition product), 2-chloro-5-nitro-4-(piperidin-1-yl)pyrimidine (67%) LCMS (m/z): 242.9 (MH+); LC Rt=4.09 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822497B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-e8307f40214a44f987c44c5c386c7361 |
| 출처 메모 | uspto-grants-2014_09 |