Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Di-tert-butyl dicarbonate → tert-Butyl (6-chloro-2-methylpyrimidin-4-yl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Di-tert-butyl dicarbonate | HCID 90495 | — |
| 반응물 | 6-Chloro-2-methylpyrimidin-4-amine | HCID 286754 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | tert-Butyl (6-chloro-2-methylpyrimidin-4-yl)carbamate | HCID 86669200 | 78% |
반응 단계
To a solution of 6-chloro-2-methylpyrimidin-4-amine (1.0 equiv.) in THF (0.17M) was added BOC2O (1.1 equiv.) and DMAP (cat.). The reaction was allowed to stir overnight, then concentrated to a yellow crude, and filtered through a pad of SiO2 eluting with EtOAc and hexanes (1:1) to afford an off-white solid (78%). LCMS (m/z): 244.1 (MH+); LC Rt=3.69 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822497B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b14ebb2ce44f4a2aa62d0ea25d21e640 |
| 출처 메모 | uspto-grants-2014_09 |