Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Di-tert-butyl dicarbonate → tert-butyl N-[6-chloro-2-(trifluoromethyl)pyrimidin-4-yl]carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Di-tert-butyl dicarbonate | HCID 90495 | — |
| 반응물 | 6-Chloro-2-(trifluoromethyl)pyrimidin-4-amine | HCID 245271 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 생성물 | tert-butyl N-[6-chloro-2-(trifluoromethyl)pyrimidin-4-yl]carbamate | HCID 87669774 | — |
반응 단계
Method 24 was followed using 6-chloro-2-(trifluoromethyl)pyrimidin-4-amine (1.0 equiv.), BOC2O (1.0 equiv.), and DMAP (cat.) to afford tert-butyl 6-chloro-2-(trifluoromethyl)pyrimidin-4-ylcarbamate in 64%. LCMS (m/z): 298.1 (MH+); LC Rt=4.73 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822497B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-6afc93268c104228859111cfbfd1091d |
| 출처 메모 | uspto-grants-2014_09 |