Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 70096생성일: 2026년 10월 24일
Ammonia → 4-Chloro-2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidine 5-oxide
https://huagongshe.com/ko/reaction/70096
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Hydrogen Peroxide | HCID 784 | — |
| 반응물 | 4-Chloro-2-[4-(4-chlorophenyl)piperazin-1-yl]-6,7-dihydrothieno[3,2-d]pyrimidine | HCID 59475917 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-Chloro-2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidine 5-oxide | HCID 59475895 | — |
반응 단계
14.69 g 4-chloro-2-[4-(4-chloro-phenyl)-piperazin-1-yl]-6,7-dihydro-thieno[3,2-d]pyrimidine are placed in 140 ml glacial acetic acid and cooled to 10° C. cooled. 3.79 ml hydrogen peroxide (35%) are added dropwise, then the mixture is stirred for 2 hours. A further 1 eq hydrogen peroxide is added, the mixture is stirred for 8 hours at ambient temperature. Then the reaction mixture is stirred into ice water, made basic with ammonia solution. The precipitate formed is suction filtered, washed with water and dried. 11.90 g of the product are obtained as a powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08822474B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-23a730fb6e334d8582e77d4885dc1479 |
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| 출처 메모 | uspto-grants-2014_09 |
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