Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydro-2-furoic acid, (+)- → ((R)-3-{2-[4-(4-CHLORO-PHENYL)-PIPERAZIN-1-YL]-5-OXO-6,7-DIHYDRO-5H-5lambda4-THIENO[3,2-D]PYRIMIDIN-4-YLAMINO}-PYRROLIDIN-1-YL)-(R)-TETRAHYDRO-FURAN-2-YL-METHANONE
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydro-2-furoic acid, (+)- | HCID 2734707 | — |
| 반응물 | {2-[4-(4-chloro-phenyl)-piperazin-1-yl]-5-oxo-6,7-dihydro-5H-5lambda4-thieno[3,2-d]pyrimidin-4-yl}-(R)-pyrrolidin-3-yl-amine | HCID 59708374 | — |
| 생성물 | ((R)-3-{2-[4-(4-CHLORO-PHENYL)-PIPERAZIN-1-YL]-5-OXO-6,7-DIHYDRO-5H-5lambda4-THIENO[3,2-D]PYRIMIDIN-4-YLAMINO}-PYRROLIDIN-1-YL)-(R)-TETRAHYDRO-FURAN-2-YL-METHANONE | HCID 59708375 | — |
반응 단계
Starting from {2-[4-(4-chloro-phenyl)-piperazin-1-yl]-5-oxo-6,7-dihydro-5H-5λ4-thieno[3,2-d]pyrimidin-4-yl}-(R)-pyrrolidin-3-yl-amine Diastereomer 1 (Example 171) (see scheme 3, 3.22) and (R)-(+)-tetrahydrofuran-2-carboxylic acid, Example 196 is prepared as described in Example 231 (see scheme 7). The product is purified by preparative HPLC (method B). Analytical HPLC-MS (method D): RT=1.18 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822474B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-f336a39b66004c97bf8c7074cb184f2a |
| 출처 메모 | uspto-grants-2014_09 |