4-(Bromomethyl)-2-chloro-1-fluorobenzene → (1S,2R)-2-[(4-Chlorobenzenesulfonyl)-(3-chloro-4fluoro-benzyl)-amino]-cyclohexanecarboxylic acid amide

참여 물질

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The titled compound was prepared in 43% yield from (1S,2R)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide (75 mg, 0.237 mmol) and 4-bromomethyl-2-chloro-1-fluoro-benzene (56 mg, 0.249 mmol) according to the procedure described for Example 3: 1H NMR (500 Mz, DMSO) δ 7.80 (d, 2 H, J=8.5), 7.63 (d, 2 H, J=8.8), 7.38–7.27 (m, 4 H), 6.67 (br s, 1 H), 4.52 (ABq, 2 H, Δv=92.1, Jab=17.1), 3.87, 2.79 (m, 1 H), 2.44 (m, 1 H), 1.78 (m, 1 H), 1.64 (m, 2 H), 1.42–1.20 (m, 3 H), 0.90 (m, 1 H); MS m/e 481.2 (M+Na)+.

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