1-(Bromomethyl)-4-(trifluoromethyl)benzene → cis-2-[(4-Chlorobenzenesulfonyl)-(4-trifluoromethyl-benzyl)-amino]-cyclohexanecarboxylic acid amide

참여 물질

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The titled compound (155 mg) was prepared in 52% yield from cis-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide and 1-bromomethyl-4-trifluoromethyl-benzene according to the procedure described in Example 11: 1H NMR (DMSO-d6) δ 7.80 (d, 2 H, J=8.6 Hz), 7.61 (m, 4 H), 7.49 (d, 2 H,J=8.0 Hz), 7.32 (s, 1 H), 6.66 (s, 1 H), 4.65 (AB2, 2 H, Δv=17, Jab=64 Hz), 3.88 (m, 1 H), 2.80 (s, 1 H), 2.44 (m, 1 H), 1.79 (m, 1 H), 1.65 (m, 2 H), 1.30 (m, 3 H), 0.92 (m, 1 H); MS m/e 475.01 (M+H)+.

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