Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 707476생성일: 2026년 10월 23일
Toluene → benzyl N-[2-[8-[(4-methoxyphenyl)methyl]-7-oxo-3,5,6,8,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,10,12-pentaen-12-yl]ethyl]carbamate
https://huagongshe.com/ko/reaction/707476
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Potassium benzyl N-[2-(trifluoroboranuidyl)ethyl]carbamate | HCID 49761741 | — |
| 반응물 | 9-bromo-6-(4-methoxybenzyl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one | HCID 86705385 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | benzyl N-[2-[8-[(4-methoxyphenyl)methyl]-7-oxo-3,5,6,8,10-pentazatricyclo[7.4.0.02,6]trideca-1(9),2,4,10,12-pentaen-12-yl]ethyl]carbamate | HCID 118116030 | 12% |
반응 단계
9-Bromo-6-(4-methoxybenzyl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one (30 mg, 0.078 mol), potassium (2-(benzyloxycarbonylamino)ethyl)trifluoroborate (30 mg, 0.11 mol), cesium carbonate (122 mg, 0.38 mmol), [1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(II) DCM complex (5 mg, 0.01 mol), toluene (0.75 ml) and degassed water (0.25 ml) were added in order. The mixture was heated at 80° C. for 16 hours, concentrated under a stream of nitrogen, diluted with DMF (1.5 mL), filtered and purified by HPLC to afford 6 mg (12%) of 204 as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09175010B2 |
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| 출처 데이터셋 | uspto-grants-2015_11 |
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| ORD ID | ord-c795aaf2365c4fc7a671eebc0e7d7320 |
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| 출처 메모 | uspto-grants-2015_11 |
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