Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxylamine → Tert-butyl 4-(4-[(hydroxyimino)methyl]-1,3-thiazol-2-yl)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxylamine | HCID 787 | — |
| 반응물 | tert-Butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate | HCID 7172298 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Tert-butyl 4-(4-[(hydroxyimino)methyl]-1,3-thiazol-2-yl)piperidine-1-carboxylate | HCID 86657567 | — |
반응 단계
To a solution of tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)piperidine-1-carboxylate (10.0 g) in ethanol (110 ml) is added dropwise hydroxylamine (50% in water, 2.48 ml). The mixture is heated to reflux for 2 hours. Volatile substances are subsequently removed under reduced pressure. This gives tert-butyl 4-{4-[(hydroxyimino)methyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate (10.5 g, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822693B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-bde58f4a26f74d58935beddfb0bf972f |
| 출처 메모 | uspto-grants-2014_09 |