Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Atorvastatin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | Atorvastatin | HCID 60823 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Atorvastatin | HCID 60823 | — |
| 생성물 | 2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, ammonium salt | HCID 73059202 | — |
반응 단계
The ammonium salt of atorvastatin was synthesized by preparing a stock solution of the free acid of atorvastatin (U.S. Pat. No. 5,273,995) in acetonitrile (ACN) (0.634 g in 25 mL of ACN). A solution was prepared by dissolving 12.04 mg of ammonium hydroxide (1.0 equivalents) in acetonitrile (0.5 mL). The stock solution of atorvastatin free acid (2.24 mL) was added to the counterion solution with stirring. If a gel formed, additional acetonitrile and water was added as necessary. After 2 days of stirring at ambient temperature, the solids were isolated by vacuum filtration using a 0.45 μm nylon 66 membrane filter. The solids were rinsed with acetonitrile and air dried at ambient conditions to afford atorvastatin ammonium.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822703B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-9e2499e4b83b4abe811afdfbf3734ae0 |
| 출처 메모 | uspto-grants-2014_09 |