Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Octyne → 5-((2'-(Trifluoromethyl)biphenyl-4-yl)ethynyl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Octyne | HCID 12370 | — |
| 반응물 | 5-Iodo-1H-indole | HCID 2782313 | — |
| 반응물 | 5-Iodo-2-tritylisoindoline | HCID 66726248 | — |
| 반응물 | 4'-Ethynyl-2-(trifluoromethyl)biphenyl | HCID 86661806 | — |
| 생성물 | 5-((2'-(Trifluoromethyl)biphenyl-4-yl)ethynyl)-1H-indole | HCID 66726787 | 86% |
반응 단계
When the product of Step A was substituted for 1-octyne and 5-iodoindole was substituted for 5-iodo-2-tritylisoindoline in Example 2, Step D, the similar process afforded the title compound in 86% yield, as a colourless paste. 1H-NMR (CDCl3) 7.56 (broad s, 1H); 7.28-7.4 (m, 5H); 7.46 (tr, 1H, J=7.25 Hz); 7.53-7.58 (m, 3H); 7.73 (d, 1H, J=7.85 Hz); 7.87 (s, 1H); 8.23 (broad s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09181182B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-ff943ebbc5264be787413209da71d288 |
| 출처 메모 | uspto-grants-2015_11 |