Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Methyl 4-methyl-2-(methylthio)-6-(m-tolylamino)pyrimidine-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium methanethiolate | HCID 4378561 | — |
| 반응물 | Methyl 2-chloro-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate | HCID 58317549 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 4-methyl-2-(methylthio)-6-(m-tolylamino)pyrimidine-5-carboxylate | HCID 58317603 | — |
반응 단계
Methyl 2-chloro-4-methyl-6-(m-tolylamino)pyrimidine-5-carboxylate (0.078 g, 0.267 mmol) was dissolved in DMF (3 mL). Sodium thiomethoxide (0.019 g, 0.267 mmol) was added and the reaction mixture was allowed to stir at RT for 1 h. The reaction mixture was poured onto ice. The pH was adjusted to 7 with 1 N HCl. The title compound was isolated as a yellow solid by vacuum filtration (72.8 mg, 90%). [M+H] calc'd for C15H17N3O2S, 304. found, 304.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09181255B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-fc77d6b32a2c45f991148679d1b8f749 |
| 출처 메모 | uspto-grants-2015_11 |