Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 711531생성일: 2026년 10월 24일
N,N-Diisopropylmethylamine → (R)-2-(4-Chloro-2-(2,4-dimethoxybenzyl)-7-fluoro-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)-4-methylpentanamide
https://huagongshe.com/ko/reaction/711531
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N,N-Diisopropylmethylamine | HCID 547370 | — |
| 반응물 | (R)-2-Amino-4-methylpentanamide | HCID 7271815 | — |
| 반응물 | 4,6-dichloro-2-[(2,4-dimethoxyphenyl)methyl]-7-fluoro-1H,2H,3H-pyrrolo[3,4-c]pyridin-3-one | HCID 58317575 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | MeOH DCM DMF | HCID 86602994 | — |
| 생성물 | (R)-2-(4-Chloro-2-(2,4-dimethoxybenzyl)-7-fluoro-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)-4-methylpentanamide | HCID 58317560 | 33.1% |
반응 단계
A mixture of 4,6-dichloro-2-(2,4-dimethoxybenzyl)-7-fluoro-1H-pyrrolo[3,4-c]pyridin-3(2H)-one (200 mg, 0.539 mmol), (R)-2-amino-4-methylpentanamide (140 mg, 1.078 mmol), and N-isopropyl-N-methylpropan-2-amine (310 mg, 2.69 mmol) in acetonitrile (2 mL) was stirred at 85° C. for 3 d. The resulting crude material was reconstituted in MeOH/DCM/DMF (10.0 mL) and purified via preparative HPLC. The fractions were collected and stripped to dryness via rotary evaporation to yield the title compound (83 mg, 33%). [M+H] calc'd for C22H26ClFN4O4, 465. found, 465.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09181255B2 |
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| 출처 데이터셋 | uspto-grants-2015_11 |
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| ORD ID | ord-0f611d64ff7f4ba19e623cf1293411c9 |
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| 출처 메모 | uspto-grants-2015_11 |
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