Water → 2-Nitro-6-(phenylthio)benzonitrile

HRID 711711

반응식

HRID 711711 반응식
[N+]([C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[C:5]=1[C:6]#[N:7])([O-])=O.C([O-])([O-])=O.[K+].[K+].[C:21]1([SH:27])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.O>CN(C=O)C>[N+:12]([C:8]1[CH:9]=[CH:10][CH:11]=[C:4]([S:27][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:5]=1[C:6]#[N:7])([O-:14])=[O:13]

참가 물질

6

반응물 4

HCID 962WaterHCID 7969ThiophenolHCID 11430Potassium CarbonateHCID 520718Dinitrobenzonitrile

생성물 1

HCID 151982412-Nitro-6-(phenylthio)benzonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
0 °C

실험 절차

To a mixture of 2,6-dinitrobenzonitrile (2.0 g, 10.36 mmol) and K2CO3 (1.43 g, 10.36 mmol) in 5 mL of anhydrous DMF was added PhSH (1.14 ml in 5 mL of DMF) dropwise under nitrogen at 0° C. After the completion of addition, the reaction mixture was stirred at 0° C. for 0.5 hr. Then the reaction mixture was poured into 50 mL of water, the resultant precipitation was collected by filtration, washed with water and dried in the air to give the title product.

후처리

  1. additionAfter the completion of addition
  2. customthe resultant precipitation
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried in the air

출처 및 근거

ORD 기록
ord-103a63689a754403a715bb982d6222e8
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09181276B2

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