Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Dioxane hydrochloride → Ethyl 4-cyanopiperidine-4-carboxylate hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 반응물 | 1-tert-Butyl 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate | HCID 57750376 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Ethyl 4-cyanopiperidine-4-carboxylate hydrochloride | HCID 14294360 | — |
반응 단계
To an ice-cold solution of O1-tert-butyl O4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (0.4 g, 1.41 mmol) in 1,4-dioxane (10 mL) was added HCl-dioxane (4 M, 5 mL) solution. The resulting mixture was stirred at rt for 30 minutes. After completion of reaction (by TLC), solvent was evaporated to obtain the product as a solid (0.28 g). MS: 183.27 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09181234B2 |
| 출처 데이터셋 | uspto-grants-2015_11 |
| ORD ID | ord-34de48a7e7044ab0bc5ba72bcaffcbd0 |
| 출처 메모 | uspto-grants-2015_11 |