Lithium Hydroxide → [4-(4-Chloro-benzoyl)-piperidin-1-yl]-acetic acid

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To a stirred solution of [4-(4-chloro-benzoyl)-piperidin-1-yl]-acetic acid ethyl ester (1.0 g, 3.03 mmol) in 12 mL of THF and 4 mL of MeOH, was added LiOH (0.39 g, 16.14 mmol in 3 mL of water). After 3 h at ambient temperature the solvent was removed in vacuo, then diluted with 20 mL of water (pH 14). The residue was treated with 12 mL of 1 N HCl (pH 4), frozen at −78° C. then lyophilized for 24 hours to yield the title product (1.33 g, 4.70 mmol, >99% yield) with LiCl salt. MS (ESI) m/z 282.3 (M+H+); HPLC (Novapak 150×3.9 mm C-18 column: mobile phase: 35-90% acetonitrile/water with 0.1% TFA, at 2 mL/min over 2 min.) t 1.26 min.

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