Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Glycine ethyl ester, hydrochloride → HCID 22060735, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| 반응물 | Ethyl 2,6-dichloro-5-nitropyrimidine-4-carboxylate | HCID 2761044 | — |
| 반응물 | R-112 | HCID 9904854 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | HCID 22060735 | HCID 22060735 | — |
반응 단계
In a manner similar to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, with the addition of triethylamine, 2,4-dichloro-6-ethoxycarbonyl-5-nitropyrimidine and glycine ethyl ester hydrochloride were reacted to yield N2,N4-bis(ethoxycarbonylmethyl)-6-ethoxycarbonyl-5-nitro-2,4-pyrimidinediamine. 1H NMR (CDCl3): mixture of rotamers 8 8.99 and 8.80 (2bs, 1H), 6.22 and 6.00 (2bs, 1H), 4.45 (t, 2H, J=7.2 Hz), 4.31-4.21 (m, 6H), 4.14 (d, 2H, J=5.1 Hz), 1.39 (t, 3H, J=7.2 Hz), 1.34-1.28 (m, 6H); LCMS: ret. time: 26.06 min.; purity: 99%; MS (m/e): 400 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08822685B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-e61b3798c3cf4b1884b54d2ecd2083cd |
| 출처 메모 | uspto-grants-2014_09 |