Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-Methyl-4-(N-ethyl-N-(beta-hydroxyethyl)amino)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 4-Nitrobenzyl chloroformate | HCID 78205 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 생성물 | 2-Methyl-4-(N-ethyl-N-(beta-hydroxyethyl)amino)aniline | HCID 75383 | — |
반응 단계
To 50 mg of Rho575 in dimethylformamide, 53 μl of N,N′-diisopropylethylamine was added followed by 78 mg of p-nitrobenzyl chloroformate dissolved in dimethylformamide. The reaction mixture was stirred for 3 days and the solvent was removed in vacuo. The residue was dissolved in chloroform and purified on a Biotage SP4 System with a SNAP 25 g column and a chloroform methanol gradient, to give a pink product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828678B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b9f955955cb84d719a000429b1b8dc1f |
| 출처 메모 | uspto-grants-2014_09 |