Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2,5-Dichloronicotinate → Methyl 5-chloro-2-(3-(4-(trifluoromethyl)phenoxy)azetidin-1-yl)nicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2,5-Dichloronicotinate | HCID 2764318 | — |
| 반응물 | 3-[4-(Trifluoromethyl)phenoxy]azetidine | HCID 12812499 | — |
| 생성물 | Methyl 5-chloro-2-(3-(4-(trifluoromethyl)phenoxy)azetidin-1-yl)nicotinate | HCID 67958398 | 66.7% |
반응 단계
The title compound (D78) (200 mg) was prepared according to the experimental procedure described in Description 62 starting from Methyl 2,5-dichloronicotinate (160 mg, 0.775 mmol) and 3-(4-(trifluoromethyl)phenoxy)azetidine (D52) (202.13 mg, 0.903 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828987B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b6292d67aaff47f0bb1b6beedde8dae3 |
| 출처 메모 | uspto-grants-2014_09 |