Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethoxy)phenol → 5-Fluoro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethoxy)phenol | HCID 2733261 | — |
| 반응물 | Methyl 5-fluoro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate | HCID 86697878 | — |
| 생성물 | 5-Fluoro-2-(3-(3-(trifluoromethoxy)phenoxy)azetidin-1-yl)nicotinic acid | HCID 67958470 | 22.1% |
반응 단계
The title compound (D134) (27 mg) was prepared according to the experimental procedure described in Description 133 starting from Methyl 5-fluoro-2-(3-((methylsulfonyl)oxy)azetidin-1-yl)nicotinate (D71) (100 mg, 0.328 mmol) and 3-(trifluoromethoxy)phenol (0.042 ml, 0.328 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08828987B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-672015aa4a3f4268a48e9a966c42849c |
| 출처 메모 | uspto-grants-2014_09 |