Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Benzyloxybenzyl bromide → 2(R)-isopropyl-3-(3-benzyloxyphenyl)-propanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Benzyloxybenzyl bromide | HCID 1502047 | — |
| 반응물 | 3-Acetoxy-4-tert-butylbenzyl bromide | HCID 21458757 | — |
| 반응물 | N-tert-butoxycabonyl-2(R)-methyl-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(3-hydroxyphenyl)-octanoic acid (N-butyl)-amide | HCID 131719571 | — |
| 용매 | Methylenechloride Hexane | HCID 21226440 | — |
| 생성물 | 2(R)-isopropyl-3-(3-benzyloxyphenyl)-propanol | HCID 22865734 | — |
반응 단계
The N-tert-butoxycarbonyl-2(R)-methyl-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(3-hydroxyphenyl)-octanoic acid (N-butyl)amide used as starting material is prepared analogously to Example 5a)-5l), except that in step k) instead of 3-acetoxy-4-tert-butyl-benzyl bromide there is used 3-benzyloxy-benzyl bromide, so that in step i) 2(R)-isopropyl-3-(3-benzyloxy-phenyl)-propanol, Rf (dichloromethane/hexane=1:1)=0.19, is obtained directly.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05705658 |
| 출처 데이터셋 | uspto-grants-1998_01 |
| ORD ID | ord-d706b5d701dd471b87614fead785adf9 |
| 출처 메모 | uspto-grants-1998_01 |