참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cyclohexanone, 2-hydroxy- | HCID 10785 | — |
| 반응물 | Benzamidine, hydrochloride | HCID 80289 | — |
| 용매 | Ammonium Hydroxide | HCID 14923 | — |
| 생성물 | 2-phenyl-4,5,6,7-tetrahydro-1H-benzimidazole | HCID 3852296 | 37.6% |
반응 단계
To a solution of 6.3 g benzamidine hydrochloride in 60 mL ammonium hydroxide was added 4.6 g 2-hydroxycyclohexanone. The reaction mixture was heated to 90° C. for 7 hours in a sealed tube. On cooling to room temperature the crystals formed were collected by filtration and after drying yielded 3.0 g 2-phenyl-4,5,6,7,-tetrahydrobenzimidazole (Compound 136), m.p. 300°-301° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05712392 |
|---|
| 출처 데이터셋 | uspto-grants-1998_01 |
|---|
| ORD ID | ord-207d847bb60146a59b8aed75e53df056 |
|---|
| 출처 메모 | uspto-grants-1998_01 |
|---|
