Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → Ethyl 4-(2-isopropyl-1H-imidazol-1-yl)-3-nitrobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1H-Imidazole, 2-(1-methylethyl)- | HCID 123457 | — |
| 반응물 | Ethyl 4-fluoro-3-nitrobenzoate | HCID 21277355 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Ethyl 4-(2-isopropyl-1H-imidazol-1-yl)-3-nitrobenzoate | HCID 59198553 | 81.7% |
반응 단계
A mixture of ethyl 4-fluoro-3-nitrobenzoate 4.26 g, 2-isopropylimidazole 2.20 g, N,N-diisopropylethylamine 5.2 mL and acetonitrile 40 mL was heated under reflux for 24 hours. After distilling the solvent off, water was added to the residue and extracted with ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate and removed of the solvent by distillation, to provide 4.95 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829000B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-5ec2d21edca24238b918011c1f187676 |
| 출처 메모 | uspto-grants-2014_09 |