Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → HCID 9884463, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 3-Quinolinecarboxylic acid, 4-chloro-8-methoxy-, ethyl ester | HCID 304557 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | 3-Amino-4-methylthiophene-2-carboxylic acid | HCID 14989678 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | HCID 9884463 | HCID 9884463 | 31.4% |
반응 단계
The sodium salt of 3-amino-4-methylthiophene-2-carboxylic acid (7.2 g, 0.04 mol) and ethyl 8-methoxy-4-chloroquinoline-3-carboxylate (5.39 g, 0.02 mol) in toluene (75 ml), ethanol (55 ml) and glacial acetic acid (10 ml) were stirred at room temperature for five days. The solvents were removed by evaporation at reduced pressure to give a dark-green slurry. 10% aqueous sodium carbonate was added and the insoluble solid filtered off, washed well with water and dried. This material was crystallised from ethyl acetate (with charcoaling) to give the title compound as pale yellow crystals (2.15 g), m.p. 162°-164°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05049567 |
| 출처 데이터셋 | uspto-grants-1991_09 |
| ORD ID | ord-124283d1e14b45b483ee120d1584d6ba |
| 출처 메모 | uspto-grants-1991_09 |