Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dideoxycytidine → Diisopropylaminomethylene 2',3'-dideoxycytidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dideoxycytidine | HCID 24066 | — |
| 반응물 | Diisopropylformamide Dimethylacetal (>90%) | HCID 13161384 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Diisopropylaminomethylene 2',3'-dideoxycytidine | HCID 131717010 | 79.3% |
반응 단계
In a typical reaction--previously dried 2',3'-dideoxycytidine (153 mg, 0.724 mmoles) prepared by the literature procedures described above is treated with diisopropylformamide dimethylacetal (1.27 g, 7.24 mmoles) in anhydrous DMF (2 mL) under an argon atmosphere. The contents are stirred overnight and then the solvent and excess reagent are removed by rotary evaporation. The syrupy residue remaining is crystallized from ethanol-ether to give pale lemon-colored crystals (185 mg, 79%) of diisopropylaminomethylene 2',3'-dideoxycytidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05051498 |
| 출처 데이터셋 | uspto-grants-1991_09 |
| ORD ID | ord-fa786e27cfb34f2f97e82278b77890f2 |
| 출처 메모 | uspto-grants-1991_09 |