Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 6-tert-Butyl-2-[4-(3-chloropyridin-4-yl)piperazin-1-yl]-1H-benzoimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 6-tert-Butyl-2-chloro-1H-benzoimidazole | HCID 11586517 | — |
| 반응물 | 1-(3-Chloropyridin-2-yl)piperazine hydrochloride | HCID 20455074 | — |
| 생성물 | 6-tert-Butyl-2-[4-(3-chloropyridin-4-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 67400597 | — |
반응 단계
The benzoimidazole from step (b) above (0.209 g, 1 mmol), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (0.304 g, 1.3 mmol, Example 3b) and N,N-diisopropylethylamine (0.45 mL, 2.6 mmol, Aldrich) were reacted under the conditions of Example 1d to give the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 371 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07582761B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-dc9cb52a50f34f1eb8adb98af13b33b5 |
| 출처 메모 | uspto-grants-2009_09 |