Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boron trifluoride → 4-(5-Isopropyl-2-Methyl-1,3-Thiazol-4-Yl)-Phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boron trifluoride | HCID 6356 | — |
| 반응물 | Sodium Cyanide | HCID 8929 | — |
| 반응물 | Bromic acid | HCID 24445 | — |
| 반응물 | 5-Isopropyl-4-(4-Methoxy-Phenyl)-2-Methyl-1,3-Thiazole | HCID 57838363 | — |
| 촉매 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-(5-Isopropyl-2-Methyl-1,3-Thiazol-4-Yl)-Phenol | HCID 16202444 | — |
반응 단계
In the fourth step, the compound (5) prepared in the third step is reacted with bromic acid and acetic acid, sodium cyanide and dimethylsulfoxide, or tetrabutylammonium iodide and boron trifluoride.diethylether, to afford 4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)-phenol (6). Conventionally, ethanethiol is used, whereby offensive odors occur and reagent handling is difficult to the extent of being unsuitable for use in mass production. However, in the present invention, the use of the compound (5) and the above materials reacting therewith, in particular, bromic acid and acetic acid result in decreased offensive odors, low price, simple reagent handling and a drastically increased preparation yield (yield: 84%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07585979B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-125362ffe0174e0bb4b5bb8def022a0f |
| 출처 메모 | uspto-grants-2009_09 |