Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclopentanesulfonyl chloride → N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)cyclopentanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclopentanesulfonyl chloride | HCID 3717197 | — |
| 반응물 | 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine | HCID 59386306 | — |
| 생성물 | N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)cyclopentanesulfonamide | HCID 53492361 | — |
반응 단계
According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamine was reacted with cyclopentanesulfonyl chloride to obtain the desired product 1H NMR (300 MHz, CDCl5): δ 7.42 (dd, J=2.1 & 10.5 Hz, 1H), 7.36 (ddd, J=2.4, 4.8, & 9.3 Hz, 1H), 7.25 (m, 2H), 7.10 (dd, J=9.6 & 17.7 Hz, 1H), 6.67 (br s, D2O exchangeable, 1H), 6.20 (dt, J=1.5, 8.4 & 17.4 Hz, 1H), 3.53 (p, 1H), 1.80 (m, 8H); m/z=495 [M−1]−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829052B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-5a2abdf78e9641d393080be27206c270 |
| 출처 메모 | uspto-grants-2014_09 |