Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 4-(5-Bromopyrimidin-2-yl)morpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Bromo-2-chloropyrimidine | HCID 606665 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-(5-Bromopyrimidin-2-yl)morpholine | HCID 5144362 | 35.7% |
반응 단계
Potassium carbonate (0.34 g) was added to a solution of 2-chloro-5-bromo-pyrimidine (0.5 g) in DMF (20 ml). The reaction mixture was stirred at rt for 15 min. Morpholine (0.2 g) was added and the reaction mixture was stirred at rt for 2 h. The excess DMF was removed by evaporation and the residue was partitioned between H2O/EtOAc (30:30 ml) The EtOAc layer was dried (MgSO4) and evaporated to dryness to give the sub-title compound as a cream solid (0.2 g). LCMS electrospray(+ve) 246 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07592347B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-ab2a6236d2154eccafc76ab11566ee69 |
| 출처 메모 | uspto-grants-2009_09 |