참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isoamyl Nitrite | HCID 8053 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Methyl 2-aminothiazole-5-carboxylate | HCID 238005 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Methyl 1,3-thiazole-5-carboxylate | HCID 331117 | 48.5% |
반응 단계
The mixture of 2.15 g of isoamyl nitrite and 10 ml of dioxane was stirred at 80° C. under a nitrogen atmosphere. A solution of 1.23 g of 2-aminothiazole-5-carboxylic acid methyl ester (7-3) in 20 ml of dioxane was added drop wise. The mixture was refluxed for 2 hours. After cooling to room temperature 30 ml of ethyl acetate was added. The mixture was washed with brine and dried and the solvent evaporated under reduced pressure. The crude product is purified on silica, thus yielding 0.54 g (48%) of thiazol 5-carboxylic acid methyl ester (7-4).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07595334B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_09 |
|---|
| ORD ID | ord-eccbb705f0784143b2bebe17ae4e730b |
|---|
| 출처 메모 | uspto-grants-2009_09 |
|---|
