Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(3S)-pyrrolidin-3-ol → (S)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (3S)-pyrrolidin-3-ol | HCID 2733874 | — |
| 반응물 | 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide | HCID 86702595 | — |
| 생성물 | (S)-5-bromo-6-(3-hydroxypyrrolidin-1-yl)-N-(4-(trifluoromethoxy)phenyl)nicotinamide | HCID 86702636 | — |
반응 단계
The title compound was prepared in an analogous fashion to that described in Stage 8.1 using 5-bromo-6-chloro-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 2.3) and (S)-pyrrolidin-3-ol to afford an off-white crystalline powder. HPLC (Condition 4) tR=5.83 min, UPLC-MS (Condition 3) tR=1.06 min, m/z=446.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829195B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-7f8fe8431301407aa3b316be3ef96699 |
| 출처 메모 | uspto-grants-2014_09 |