Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitrobenzoyl chloride → 1-(4-Nitrobenzoyl)-1,2,3,4-tetrahydroquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(4-Nitrobenzoyl)-1,2,3,4-tetrahydroquinoline | HCID 3763693 | 67.1% |
반응 단계
To a solution of 1,2,3,4-tetrahydroquinoline (28.7 g) in acetone (400 ml) and water (200 ml) is added potassium carbonate (38.8 g), and thereto is added p-nitrobenzoyl chloride (40 g) under ice-cooling and the mixture is stirred at room temperature overnight. To the reaction mixture is added a suitable amount of water. The precipitated crystal is collected by filtration and dried to give 1-(4-nitrobenzoyl)-1,2,3,4-tetrahydroquinoline (40.8 g) as white powder, m.p. 86°-88° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05559230 |
| 출처 데이터셋 | uspto-grants-1996_09 |
| ORD ID | ord-63d41ead927446428359ba9f90e1f857 |
| 출처 메모 | uspto-grants-1996_09 |