Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-Indole-3-propanoic acid → 3-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-Indole-3-propanoic acid | HCID 3744 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one | HCID 4806783 | — |
반응 단계
681 mg (3.60 mmol) 3-(1H-indol-3-yl)-propionic acid, 0.3 mL (3.60 mmol) pyrrolidine, 1.13 g (3.50 mmol) TBTU and 0.98 mL (7.00 mmol) triethylamine in 5.0 mL DMF were stirred overnight at RT. The mixture was purified by preparative HPLC. The product fractions were combined and evaporated down i. vac.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-1df2c89023ab44e3bf397e899e470f39 |
| 출처 메모 | uspto-grants-2014_09 |