Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → 1-Methyl-1-benzyl-4-[3-(4-tert.-butylphenyl)-2-methylpropyl]-piperazinium bromide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | 1-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine | HCID 13251981 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Methyl-1-benzyl-4-[3-(4-tert.-butylphenyl)-2-methylpropyl]-piperazinium bromide | HCID 13251982 | 80.2% |
반응 단계
A solution of 14.4 g of 1-methyl-4-[3-(4-tert.-butylphenyl)-2-methylpropyl]-piperazine and 10.3 g of benzyl bromide in 200 ml of ethyl acetate was refluxed for 6 hours, after which the mixture was evaporated down to 80 ml and then cooled to +5° C. The precipitated product was filtered off under suction, washed with ether and dried. 18.4 g of 1-methyl-1-benzyl-4-[3-(4-tert.-butylphenyl)-2-methylpropyl]-piperazinium bromide were obtained in the form of colorless crystals of melting point 216° C. (compound 3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04599335 |
| 출처 데이터셋 | uspto-grants-1986_07 |
| ORD ID | ord-bd19a1f8882144ec99b21925d36208f7 |
| 출처 메모 | uspto-grants-1986_07 |