Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → (2-Chloro-6-methoxypyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 5-Fluoroindoline | HCID 2774463 | — |
| 반응물 | 2-Chloro-6-methoxypyridine-4-carboxylic acid | HCID 2782124 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (2-Chloro-6-methoxypyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone | HCID 58386441 | — |
반응 단계
0.50 g (2.7 mmol) 2-chloro-6-methoxyisonicotinic acid, 0.37 g (2.7 mmol) 5-fluoroindoline and 0.42 mL (3 mmol) TEA were in 10 mL DMF placed. 0.97 g (3.0 mmol) TBTU were added and the reaction mixture was 2 h stirred at RT. The substance was purified by HPLC. The product-containing fractions were combined and freeze-dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-2aaf8833422d4f5c929e77143a2dbfe9 |
| 출처 메모 | uspto-grants-2014_09 |