Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → HCID 86071219, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Bromoacetyl bromide | HCID 61147 | — |
| 반응물 | 6-Nitroveratryl alcohol | HCID 66097 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | HCID 86071219 | HCID 86071219 | 55.1% |
반응 단계
Bromoacetylbromide (0.19 ml, 2.2 mmol) was slowly added to the solution of 6-nitroveratrylalcohol (0.43 g, 2 mmol), Et3N (0.56 ml, 4 mmol) and DMAP (24 mg, 0.2 mmol) in CHCl3 (5 ml). After stirring at room temperature for five hours, CH2Cl2 (20 ml) was added and the mixture was washed with HCl (1 M, 2×10 ml), NaHCO3 (sat., 10 ml) and water (10 ml). Organic phase was dried over Na2SO4, evaporated and purified by chromatography (Si-gel, CH2Cl2) to yield 4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate (368 mg, 55%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07393828B2 |
| 출처 데이터셋 | uspto-grants-2008_07 |
| ORD ID | ord-7be346b8d40a48e3b16b2cdd7e8b52d1 |
| 출처 메모 | uspto-grants-2008_07 |