Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-2-fluoroaniline → N-(4-chloro-2-fluorophenyl)-6-methoxy-7-(2-methoxyethoxy)cinnolin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-2-fluoroaniline | HCID 93898 | — |
| 반응물 | 4-Chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline | HCID 10707048 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(4-chloro-2-fluorophenyl)-6-methoxy-7-(2-methoxyethoxy)cinnolin-4-amine | HCID 6326408 | — |
반응 단계
A solution of 4-chloro-6-methoxy-7-(2-methoxyethoxy)cinnoline (0.4 g, 1.5 mmol), (prepared as described for the starting material in Example 2), and 4-chloro-2-fluoroaniline (282 μl, 2.5 mmol) in DMF (5 ml) was treated as described in Example 2, to give 4-(4-chloro-2-fluoroanilino)-6-methoxy-7-(2-methoxyethoxy)cinnoline as the hydrochloride salt (450 mg, 72%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087602B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-a7456a49a4744a4b88f2eea3063a6601 |
| 출처 메모 | uspto-grants-2006_08 |