Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-2-methylphenol → 4-(3-Hydroxy-4-methylanilino)-7-methoxycinnoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-2-methylphenol | HCID 17818 | — |
| 반응물 | 4-Chloro-7-methoxycinnoline hydrochloride | HCID 21991020 | — |
| 용매 | 2-Pentanol | HCID 22386 | — |
| 생성물 | 4-(3-Hydroxy-4-methylanilino)-7-methoxycinnoline | HCID 21991010 | — |
반응 단계
A suspension of 4-chloro-7-methoxycinnoline hydrochloride (196 mg, 0.85 mmol) and 3-hydroxy-4-methylaniline (123 mg, 1 mmol) in 2-pentanol (5 ml) was heated at reflux for 2 hours. After cooling, the solid was filtered off, washed with isopropanol, ether and dried under vacuum to give 4-(3-hydroxy-4methylanilino)-7-methoxycinnoline as the hydrochloride salt (yellow solid, 215 mg, 80%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087602B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-6d27b32ced974eb7a6b88307c6cfb13f |
| 출처 메모 | uspto-grants-2006_08 |