Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl chloroformate → Benzyl ((1S,3R)-3-aminocyclohexyl)carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl chloroformate | HCID 6586 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Carbonic Acid 2,5-Dioxopyrrolidin-1-yl (S)-Tetrahydrofuran-3-yl Ester | HCID 11229944 | — |
| 반응물 | 5-Chloro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine | HCID 67285321 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Benzyl ((1S,3R)-3-aminocyclohexyl)carbamate | HCID 69756715 | — |
반응 단계
MeOCOCl, Et3N, THF; (b) H2, Pd/C, EtOH; (c) 5-chloro-3-(5-fluoro-4-methylsulfinyl-pyrimidin-2-yl)-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine, THF, 130° C., microwave; (d) LiOH, 130° C., microwave.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829007B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-e43af7c4d88c4463b7d15dbe7f02a353 |
| 출처 메모 | uspto-grants-2014_09 |